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mellowsong
11-14-09, 01:06 PM
The study, conducted at KGK Synergize Inc. (“KGK”), a contract research organization located in London, Ontario, was recently published in Urologic Nursing, and identifies that there was a significant change in 24-hour urine oxalate levels among two treatments. The study was conducted as a randomized, double-blind, crossover trial of vitamin C with metabolites (Ester-C®) compared to ascorbic acid in 50 healthy adults.

Subjects on a controlled diet ingested 1000 mg/day vitamin C with metabolites for 5 days and 2000 mg/day for an additional 5 days, and urine oxalate was measured. After a 7 day washout, participants repeated the same protocol (crossed over) with the alternative form of vitamin C. There was a significant change in the urine oxalate levels between the two treatments. Approximately 25% more subjects experienced a reduction in 24-hour oxalate (59% to 34%) and oxalate concentration (72% to 46%) over the 10 day period when taking vitamin C with metabolites compared to ascorbic acid.

According to Mark A. Moyad, MD, a research consultant for The Ester C Company, “these results are very promising and worthy of further clinical evaluation”.

About KGK Synergize Inc:

KGK provides contract research services to the health nutrition, biotechnology and pharmaceutical industries. These services include both pre-clinical and human clinical trials.

In addition to its contract research capabilities, KGK has a Product Development Division which brings new and innovative natural health products to the point where they are ready to be manufactured and marketed. These products include Sytrinol®, DiabetinolTM and DermytolTM.

http://www.npicenter.com/anm/templates/newsATemp.aspx?form_372.replyids=1&form_363.replyids=1&form_346.userid=215&form_346.replyids=4879&articleid=25581&zoneid=28
PS....Islander, feel free to tiny URL these because it refuses to work on my computer :)

Islander
11-14-09, 04:27 PM
Mellowsong, can you interpret this for us who don't have a medical background? Can you please explain metabolites and oxalates? Thanks!

mellowsong
11-15-09, 01:30 PM
Mellowsong, can you interpret this for us who don't have a medical background? Can you please explain metabolites and oxalates? Thanks!
Sorry :) Ok, they've known for a long time that vitamin C can reduce oxalates in the urine. Oxalates are the cause of the majority of kidney stones. An old time honored trick that works is to drink 1/4 cup lemon juice/day and it will prevent stones.

What this article is saying is plain ol' ascorbic acid did reduce oxalates but when they gave Vitamin C in the form of Ester-C oxalate reduction was much better. The metabolites in Ester C are mineral salts such as calcium threonate which enhance absorption of Vitamin C into the tissues and stabilize Vitamin C.

Hope this helps.

Islander
11-15-09, 04:28 PM
Yes, thanks!