Islander
06-12-10, 01:50 PM
http://www.lef.org
June 11, 2010
Leukemia refers to cancers that begin in the blood-forming cells of the body. These abnormal cells grow and multiply in an uncontrolled way. As the disease progresses, leukemic cells move through the bloodstream and invade other organs, such as the spleen, lymph nodes, liver, and central nervous system. In the US, more than 30,000 new cases of leukemia are diagnosed every year, and adult onset accounts for 90 percent of the new cases (Xie Y et al 2003).
Leukemia can be classified into four major types based on whether the disease is acute or chronic and according to the type of white blood cell affected:
Acute myelogenous leukemia (AML)
Chronic myelogenous leukemia (CML)
Acute lymphocytic leukemia (ALL)
Chronic lymphocytic leukemia (CLL) An extract of the spice turmeric, curcumin acts in combination with the soy isoflavone genistein to reduce the number of leukemia-promoting properties, such as growth signals and pro-inflammatory cytokines that are over-produced in leukemia (Arbiser JL et al 1998). Curcumin has been shown to:
Inhibit production of bFGF, a potent growth signal for cancer cells that is known to be over-produced in AML, CML, and ALL (Arbiser JL et al 1998).
Increase expression of the cancer-protective p53 gene in leukemia cell lines, thus making them more susceptible to cell death (Jee SH et al 1998).
Reduce the production of the inflammatory cytokine, TNF-alpha, that is over-produced in CML and ALL (Xu YX et al 1997). Epigallocatechin gallate (EGCG) in green tea blocks the production of vascular endothelial growth factor (VEGF), considered essential for leukemia growth and spread (Lee YK et al 2004). EGCG may be particularly useful in CLL, a leukemia type that relies heavily on VEGF for its survival. EGCG significantly increased the rate of cell death in 8 out of 10 CLL samples (Lee YK et al 2004). Green tea blocks the proliferation of lymphocytes from adult T cell leukemia patients (Li HC et al 2000). Theaflavins found in black tea have also been shown to be as potent as EGCG from green tea in blocking proliferation of leukemia cell lines (Lung HL et al 2004)
http://tinyurl.com/33cbvgo
June 11, 2010
Leukemia refers to cancers that begin in the blood-forming cells of the body. These abnormal cells grow and multiply in an uncontrolled way. As the disease progresses, leukemic cells move through the bloodstream and invade other organs, such as the spleen, lymph nodes, liver, and central nervous system. In the US, more than 30,000 new cases of leukemia are diagnosed every year, and adult onset accounts for 90 percent of the new cases (Xie Y et al 2003).
Leukemia can be classified into four major types based on whether the disease is acute or chronic and according to the type of white blood cell affected:
Acute myelogenous leukemia (AML)
Chronic myelogenous leukemia (CML)
Acute lymphocytic leukemia (ALL)
Chronic lymphocytic leukemia (CLL) An extract of the spice turmeric, curcumin acts in combination with the soy isoflavone genistein to reduce the number of leukemia-promoting properties, such as growth signals and pro-inflammatory cytokines that are over-produced in leukemia (Arbiser JL et al 1998). Curcumin has been shown to:
Inhibit production of bFGF, a potent growth signal for cancer cells that is known to be over-produced in AML, CML, and ALL (Arbiser JL et al 1998).
Increase expression of the cancer-protective p53 gene in leukemia cell lines, thus making them more susceptible to cell death (Jee SH et al 1998).
Reduce the production of the inflammatory cytokine, TNF-alpha, that is over-produced in CML and ALL (Xu YX et al 1997). Epigallocatechin gallate (EGCG) in green tea blocks the production of vascular endothelial growth factor (VEGF), considered essential for leukemia growth and spread (Lee YK et al 2004). EGCG may be particularly useful in CLL, a leukemia type that relies heavily on VEGF for its survival. EGCG significantly increased the rate of cell death in 8 out of 10 CLL samples (Lee YK et al 2004). Green tea blocks the proliferation of lymphocytes from adult T cell leukemia patients (Li HC et al 2000). Theaflavins found in black tea have also been shown to be as potent as EGCG from green tea in blocking proliferation of leukemia cell lines (Lung HL et al 2004)
http://tinyurl.com/33cbvgo