mellowsong
07-29-11, 09:34 PM
Authors: Kieren G Hollingsworth PhD1, Tim Hodgson DCR(R)1, Guy A MacGowan MD FACC FRCPI3, Andrew M Blamire PhD1, Julia L Newton MD PhD2 No Date
Article accepted for but not yet published in Journal of Internal Medicine.
Objectives: Impaired cardiac function has been confirmed in patients with chronic fatigue syndrome (CFS). Magnetic resonance cardiac tagging is a novel technique that assesses myocardial wall function in vivo. We hypothesized that CFS patients may have impaired development and release of myocardial torsion and strain.
Methods: Cardiac morphology and function was assessed using magnetic resonance imaging and cardiac tagging methodology in 12 CFS (Fukuda) and 10 matched controls.
Results: Compared to controls the CFS group had substantially reduced LV mass (reduced by 23%), end diastolic volume (30%), stroke volume (29%), and cardiac output (25%). Residual torsion at 150% of the end-systolic time was found to be significantly higher in the CFS patients (5.3±1.6o) compared to the control group (1.7±0.7o, p=0.0001). End diastolic volume index correlated negatively with both torsion to endocardial strain ratio (TSR) (r =-0.65, p=0.02) and the residual torsion at 150% end systolic time (r=-0.76, p=0.004), so decreased end diastolic volume is associated with raised TSR and torsion persisting longer into diastole. Reduced end diastolic volume index also correlated significantly with increased radial thickening (r=-0.65, p=0.03) and impaired diastolic function represented by the ratio of early to late ventricular filling velocity (E/A ratio, r=0.71, p=0.009) and early filling percentage (r=0.73, p=0.008).
Conclusion: CFS patients have markedly reduced cardiac mass and blood pool volumes, particularly end diastolic volume: this results in significant impairments in stroke volume and cardiac output compared to controls. The CFS group appeared to have a delay in the release of torsion.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02429.x/abstract
Article accepted for but not yet published in Journal of Internal Medicine.
Objectives: Impaired cardiac function has been confirmed in patients with chronic fatigue syndrome (CFS). Magnetic resonance cardiac tagging is a novel technique that assesses myocardial wall function in vivo. We hypothesized that CFS patients may have impaired development and release of myocardial torsion and strain.
Methods: Cardiac morphology and function was assessed using magnetic resonance imaging and cardiac tagging methodology in 12 CFS (Fukuda) and 10 matched controls.
Results: Compared to controls the CFS group had substantially reduced LV mass (reduced by 23%), end diastolic volume (30%), stroke volume (29%), and cardiac output (25%). Residual torsion at 150% of the end-systolic time was found to be significantly higher in the CFS patients (5.3±1.6o) compared to the control group (1.7±0.7o, p=0.0001). End diastolic volume index correlated negatively with both torsion to endocardial strain ratio (TSR) (r =-0.65, p=0.02) and the residual torsion at 150% end systolic time (r=-0.76, p=0.004), so decreased end diastolic volume is associated with raised TSR and torsion persisting longer into diastole. Reduced end diastolic volume index also correlated significantly with increased radial thickening (r=-0.65, p=0.03) and impaired diastolic function represented by the ratio of early to late ventricular filling velocity (E/A ratio, r=0.71, p=0.009) and early filling percentage (r=0.73, p=0.008).
Conclusion: CFS patients have markedly reduced cardiac mass and blood pool volumes, particularly end diastolic volume: this results in significant impairments in stroke volume and cardiac output compared to controls. The CFS group appeared to have a delay in the release of torsion.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02429.x/abstract