View Full Version : The search for reliable biomarkers of disease in MCS and otherl intolerances

08-17-11, 08:01 PM
The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances.

De Luca C (http://www.ncbi.nlm.nih.gov/pubmed?term=%22De%20Luca%20C%22%5BAuthor%5D), Raskovic D (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Raskovic%20D%22%5BAuthor%5D), Pacifico V (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Pacifico%20V%22%5BAuthor%5D), Thai JC (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Thai%20JC%22%5BAuthor%5D), Korkina L (http://www.ncbi.nlm.nih.gov/pubmed?term=%22Korkina%20L%22%5BAuthor%5D)
Int J Environ Res Public Health. (http://www.ncbi.nlm.nih.gov/pubmed/21845158#) 2011 Jul;8(7):2770-97. Epub 2011 Jul 1.


Whilst facing a worldwide fast increase of food and environmental allergies, the medical community is also confronted with another inhomogeneous group of environment-associated disabling conditions, including multiple chemical sensitivity (MCS), fibromyalgia, chronic fatigue syndrome, electric hypersensitivity, amalgam disease and others. These share the features of poly-symptomatic multi-organ cutaneous and systemic manifestations, with postulated inherited/acquired impaired metabolism of chemical/physical/nutritional xenobiotics, triggering adverse reactions at exposure levels far below toxicologically-relevant values, often in the absence of clear-cut allergologic and/or immunologic involvement. Due to the lack of proven pathogenic mechanisms generating measurable disease biomarkers, these environmental hypersensitivities are generally ignored by sanitary and social systems, as psychogenic or "medically unexplained symptoms". The uncontrolled application of diagnostic and treatment protocols not corresponding to acceptable levels of validation, safety, and clinical efficacy, to a steadily increasing number of patients demanding assistance, occurs in many countries in the absence of evidence-based guidelines. Here we revise available information supporting the organic nature of these clinical conditions.

Read more: http://www.ncbi.nlm.nih.gov/pubmed/21845158