View Full Version : Hypothalamic–Pituitary–Adrenal Axis Dysfunction in Chronic Fatigue Syndrome

09-30-11, 06:18 PM
Andrew S. Papadopoulos & Anthony J. Cleare
27 Sept 2011

The weight of current evidence supports the presence of the following factors related to hypothalamic–pituitary–adrenal (HPA) axis dysfunction in patients with chronic fatigue syndrome (CFS): mild hypocortisolism; attenuated diurnal variation of cortisol; enhanced negative feedback to the HPA axis; and blunted HPA axis responsiveness. Furthermore, HPA axis changes seem clinically relevant, as they are associated with worse symptoms and/or disability and with poorer outcomes to standard treatments for CFS. Regarding etiology, women with CFS are more likely to have reduced cortisol levels.

Read more: http://www.nature.com/nrendo/journal/vaop/ncurrent/abs/nrendo.2011.153.html

09-30-11, 06:20 PM
This article ends in suggesting this dysfunction can be fixed with cognitive behavioral therapy! I only put it here so that anyone with CFIDS can be forewarned that the idiots are still trying to put this back in the realm of a mental health disorder. Unbelievable considering the first sentence admits that the scientific evidence of this is there! This kind of article makes me so angry! Just drug us and make us shut up and go away...right?

"In particular, low activity levels, depression and early-life stress appear to reduce cortisol levels, whereas the use of psychotropic medication can increase cortisol. Addressing these factors—for example, with cognitive behavioral therapy—can increase cortisol levels"