This is from an e-mail.

Trudy Scott, CN
April 11, 2015

I recently blogged about the possible connection between oxytocin, social anxiety, pyroluria and depression and would like to share that there is also a connection between autism, low oxytocin and social anxiety, and possibly pyroluria too.

It's Autism Awareness Month so I'd like to share a video from Dr. Kurt Woeller D.O., an integrative medicine physician and biomedical autism specialist. He is also a lecturer, educator, and experienced practicing clinician offering specialized diagnostic testing and treatment for individuals with complex medical conditions like autism, mental health disorders, multiple sclerosis, and other chronic health conditions.

Dr. Woeller shares how helpful oxytocin is social anxiety, facial recognition and voice recognition in individuals with autism and Asperger's syndrome

"An interesting therapy for certain individuals on the autism spectrum is something called oxytocin. Oxytocin is a hormone that is produced in our bodies and it has a wide range of effects. When a woman is in labor, oxytocin helps with uterine contractions so it is useful for the delivery of the baby. When a mother is breastfeeding her newborn, oxytocin can be released and it is felt that oxytocin helps with mother to child bonding that occurs with breastfeeding.

This is important for human to human interaction. Oxytocin is also released during physical contact between two people, and we know it is released in large amounts particularly during sexual intercourse.

As a therapy, oxytocin has been very helpful particularly for social anxiety. There are a couple of other effects that are interesting with oxytocin. Oxytocin seems to help with facial cue recognition. That enables us to tell the difference between a happy face, sad face, inquisitive face, etc. It also helps with voice cue recognition as well.

They did a study with adults on the autism spectrum and who had Asperger's as well and they gave them an IV infusion of oxytocin and then measured their response over a two week period of time. What they found was that the individuals that received the oxytocin did much better at looking at pictures of different facial expressions and picking out the differences as well as listening to recordings of different voice emotional cues: an angry voice, a happy voice, etc.

Oxytocin is a useful remedy to consider particularly if the child, teenager or adult that you know has social anxiety issues or lacks the recognition of facial and/or voice cues.

Oxytocin comes as a nasal spray and does need to be prepared by a compounding pharmacy.

Usually you dose oxytocin once a day, maybe twice a day or even as needed situationally. You can give oxytocin before going into a situation where your child has a problem with social anxiety."

Dr Woeller uses the Meridian Valley Lab 24-hr urinary oxytocin test which, according to them "is the best method to capture the pulsatile peaks and valleys of oxytocin production." You can order the test (and interpretation) via his testing site Lab Tests Plus.

There are a number of studies that support the use of oxytocin for improving eye-contact, facial recognition and social anxiety:

Here is a snippet from my book The Antianxiety Food Solution on the estimates of the prevalence of pyroluria (be aware that can vary depending on the type of clients/patients a practitioner works with):
Joan Mathews-Larson, considered an expert on the subject, reports the prevalence as follows: 11 percent of the healthy population, 40 percent of adults with psychiatric disorders, 25 percent of children with psychiatric disorders, 30 percent of people with schizophrenia, and 40 percent of alcoholics.

Abram Hoffer worked primarily with schizophrenic patients, but he found pyroluria was also present in 25 percent of his nonschizophrenic patients, including adults with anxiety, depression, and alcoholism, and children with learning disorders and behavioral disorders.

According to McGinnis, pyroluria is also present in about 46 percent of people with autism spectrum disorders and 71 percent of those with Down syndrome.

I work primarily with adult women who are anxious, depressed, or both and have found that at least 80 percent of my clients with moderate to severe anxiety have a large number of pyroluria symptoms.

Based on this and the research we're seeing on autism, social anxiety and oxytocin, I would expect that if you have pyroluria you may also have low levels of oxytocin and may need to address this, especially if you not getting complete resolution with the zinc, vitamin B6 and evening primrose oil.

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Trudy Scott (CN), Certified Nutritionist is the founder of, a thriving nutrition practice with a focus on food, mood and women's health. Trudy educates women about the amazing healing powers of food and nutrients and helps them find natural solutions for anxiety and other mood problems. Trudy's goal for all her clients (and all women): "You can be your healthiest, look your best and feel on-top-of-the-world emotionally!"

© 2015 Trudy Scott