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Thread: Manuka honey can eradicate different biofilms produced by MRSA strains

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    Default Manuka honey can eradicate different biofilms produced by MRSA strains

    PeerJ. 2014; 2: e326.
    2014 Mar 25. doi: 10.7717/peerj.326
    PMCID: PMC3970805

    Manuka-type honeys can eradicate biofilms produced by Staphylococcus aureus strains with different biofilm-forming abilities

    Jing Lu,1 Lynne Turnbull,1 Catherine M. Burke,1 Michael Liu,1 Dee A. Carter,2 Ralf C. Schlothauer,3 Cynthia B. Whitchurch,1 and Elizabeth J. Harry1
    Academic Editor: Siouxsie Wiles

    Abstract

    Chronic wounds are a major global health problem. Their management is difficult and costly, and the development of antibiotic resistance by both planktonic and biofilm-associated bacteria necessitates the use of alternative wound treatments. Honey is now being revisited as an alternative treatment due to its broad-spectrum antibacterial activity and the inability of bacteria to develop resistance to it. Many previous antibacterial studies have used honeys that are not well characterized, even in terms of quantifying the levels of the major antibacterial components present, making it difficult to build an evidence base for the efficacy of honey as an antibiofilm agent in chronic wound treatment. Here we show that a range of well-characterized New Zealand manuka-type honeys, in which two principle antibacterial components, methylglyoxal and hydrogen peroxide, were quantified, can eradicate biofilms of a range of Staphylococcus aureus strains that differ widely in their biofilm-forming abilities. Using crystal violet and viability assays, along with confocal laser scanning imaging, we demonstrate that in all S. aureus strains, including methicillin-resistant strains, the manuka-type honeys showed significantly higher anti-biofilm activity than clover honey and an isotonic sugar solution. We observed higher anti-biofilm activity as the proportion of manuka-derived honey, and thus methylglyoxal, in a honey blend increased. However, methylglyoxal on its own, or with sugar, was not able to effectively eradicate S. aureus biofilms. We also demonstrate that honey was able to penetrate through the biofilm matrix and kill the embedded cells in some cases. As has been reported for antibiotics, sub-inhibitory concentrations of honey improved biofilm formation by some S. aureus strains, however, biofilm cell suspensions recovered after honey treatment did not develop resistance towards manuka-type honeys. New Zealand manuka-type honeys, at the concentrations they can be applied in wound dressings are highly active in both preventing S. aureus biofilm formation and in their eradication, and do not result in bacteria becoming resistant. Methylglyoxal requires other components in manuka-type honeys for this anti-biofilm activity. Our findings support the use of well-defined manuka-type honeys as a topical anti-biofilm treatment for the effective management of wound healing.

    Read the entire text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970805/
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    Veteran Member Maurya's Avatar
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    Default Re: Manuka honey can eradicate different biofilms produced by MRSA strains

    It would be nice to know if there is a way to determine a "Manuka type" honey that is local in origin. Honey made from local pollen sources would be much better tailored to the beings who live in that local area.

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    Default Re: Manuka honey can eradicate different biofilms produced by MRSA strains

    Except that, as I understand it, Manuka honey is made from the Manuka tree, sometimes called the tea tree. It is indigenous to New Zealand. I am unaware that any attempt to propagate it in other parts of the world has succeeded. The best price I've found yet is from vitacost, with a high active rating of 15+, which is pretty darned high.
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    Moderator Julieanne's Avatar
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    Default Re: Manuka honey can eradicate different biofilms produced by MRSA strains

    We have a variety of this tree in Australia. As the article below explains, Manuka is the Maori word for tea tree, and the NZ producers want to keep the two terms separate. The Oz type seems to be just as effective according to this:

    http://www.abc.net.au/news/2016-12-2...ealand/8151996

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    Default Re: Manuka honey can eradicate different biofilms produced by MRSA strains

    Wow, Julie. That flower looked astonishingly like our passionflower, Passiflora incarnata. Compare: https://chapelofhopestories.com/2015...-flower-bloom/

    I always wonder how anyone can be sure that a harvest of honey comes only from the tea tree. The beekeepers must know....
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    Default Re: Manuka honey can eradicate different biofilms produced by MRSA strains

    But it's much, much smaller - little clusters all over the bush/tree. I guess it's not hot enough for your passion flower to turn into fruit? Haven't grown a vine successfully since the neighbour's tree roots took over the garden, but I used to give passionfruit away by the bagful!

    Yes, I wonder too, how do the beekeepers know? I have my favourite honeys that I can buy locally. all labelled with the names of the eucalypts they came from. I think it is to do with timing - they move the hives around when certain trees are in bloom.

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    Default Re: Manuka honey can eradicate different biofilms produced by MRSA strains

    That's it — of course, the bloom period!

    No, my passionflower was strictly ornamental. Unfamiliar with passionfruit.
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