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Thread: The Effect of Vitamin D on Cancer Incidence and Survival

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    Administrator Islander's Avatar
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    Default The Effect of Vitamin D on Cancer Incidence and Survival

    FOR IMMEDIATE RELEASE
    Orthomolecular Medicine News Service, July 15, 2019
    William B. Grant

    (OMNS July 15, 2019) The results of a phase 2 randomized controlled trial (RCT) of high- vs. low-dose vitamin D3 supplementation for 139 patients with advanced colorectal cancer taking chemotherapy was recently reported in JAMA [Ng et al., 2019]. The high-dose vitamin D treatment was 8000 IU/d vitamin D3 for two weeks, then 4000 IU/d thereafter. The low-dose treatment group received 400 IU/d vitamin D3. The length of time before the disease worsened was 13 months in the high-dose treatment group and 11 months in the low-dose group. Further, high-dose vitamin D3 supplementation significantly reduced the risk of death by 36% (P = 0.02). In secondary analyses, the length of time before the disease worsened was significantly longer for patients in the treatment group who maintained a healthy weight, or had more metastatic sites.
    The rate of diarrhea was 12% in the low-dose group, but only 1% in the high-dose group. This finding is consistent with the role of vitamin D in maintenance of gut mucosal barrier integrity.

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    Default Re: The Effect of Vitamin D on Cancer Incidence and Survival

    My research over time holds that 8000 IU/d is a maintenance dose, not a high dose, whereas 400 IU is barely enough to avoid a serious deficiency. I speculate that at doses of 20,000 or even 30,000/day for the length of the study would have demonstrated even more encouraging results.
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    Veteran Member Mr. Wizard's Avatar
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    Default Re: The Effect of Vitamin D on Cancer Incidence and Survival

    No wonder that vitamin D3 supplementation helped to improve the condition of these cancer patients. Of importance to note: ****Vitamin D3 is a "hormone," not a vitamin. It was misnamed as a vitamin in 1969 and was never corrected. Almost every cell in the body has vitamin D receptors, which helps to explain how vit. D3 influences thousands of processes in the body. Chemotherapy drugs can cause damage to the liver, kidneys, and the colon. So, it is likely that the addition of vit. D3 supplementation for these patients was a major factor in diminishing the damage done by the chemotherapy drugs. **Finally, I was puzzled to see that although the high-dose patients received 20 times more vit. D3 than the low-dose patients, the high-dose patients only received 2 months more before their conditions worsened than the low-dose group. Seems really curious??

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