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Thread: The Effect of Vitamin D on Cancer Incidence and Survival

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    Default The Effect of Vitamin D on Cancer Incidence and Survival

    FOR IMMEDIATE RELEASE
    Orthomolecular Medicine News Service, July 15, 2019
    William B. Grant

    (OMNS July 15, 2019) The results of a phase 2 randomized controlled trial (RCT) of high- vs. low-dose vitamin D3 supplementation for 139 patients with advanced colorectal cancer taking chemotherapy was recently reported in JAMA [Ng et al., 2019]. The high-dose vitamin D treatment was 8000 IU/d vitamin D3 for two weeks, then 4000 IU/d thereafter. The low-dose treatment group received 400 IU/d vitamin D3. The length of time before the disease worsened was 13 months in the high-dose treatment group and 11 months in the low-dose group. Further, high-dose vitamin D3 supplementation significantly reduced the risk of death by 36% (P = 0.02). In secondary analyses, the length of time before the disease worsened was significantly longer for patients in the treatment group who maintained a healthy weight, or had more metastatic sites.
    The rate of diarrhea was 12% in the low-dose group, but only 1% in the high-dose group. This finding is consistent with the role of vitamin D in maintenance of gut mucosal barrier integrity.

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    Default Re: The Effect of Vitamin D on Cancer Incidence and Survival

    My research over time holds that 8000 IU/d is a maintenance dose, not a high dose, whereas 400 IU is barely enough to avoid a serious deficiency. I speculate that at doses of 20,000 or even 30,000/day for the length of the study would have demonstrated even more encouraging results.
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