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Thread: In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

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    Administrator Islander's Avatar
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    Default In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

    Rob Stein
    July 29, 2019

    For the first time, doctors in the U.S. have used the powerful gene-editing technique CRISPR to try to treat a patient with a genetic disorder.
    "It is just amazing how far things have come," says Victoria Gray, 34, of Forest, Miss. "It is wonderful," she told NPR in an exclusive interview after undergoing the landmark treatment for sickle cell disease.
    Gray is the first patient ever to be publicly identified as being involved in a study testing the use of CRISPR for a genetic disease.

    Read more: https://www.npr.org/sections/health-...tm_id=35269681
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    Default Re: In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

    If a person were being treated with a medication for a condition, and it wasn't helping, or might even be harmful, the medication could be discontinued. But when you are replacing genes, messing around with DNA, the results are permanent. Think about that.
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    Default Re: In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

    "Many people with sickle cell disease don't live past their 40s." So what did she have to lose? Reading the article, the doctors seem to be acting cautiously, which is not always the case.

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    Veteran Member Mr. Wizard's Avatar
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    Default Re: In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

    I hope and pray this CRISPR procedure is successful for the sake of the millions of people around the world dealing with sickle cell abnormalities. Sickle cell strikes mostly people from South & Central America (especially Panama), the Caribbean islands, Mediterranean countries (like Turkey, Greece, Italy), Saudi Arabia, India, and Sub-Saharan African countries. In the U.S., some form of sickle abnormality affects 1 out of every 375 African American babies. **It is important to note this story is about a woman with "sickle cell anemia," which means she inherited 2 abnormal hemoglobin genes (1 from each parent). However, according to the American Society of Hematology, up to 3 million Americans live with a less harmful form of the illness, called "sickle cell trait," where the person inherited only 1 abnormal gene. The Hematology Society reports that more than 100 million people around the world have sickle cell trait. If CRISPR is successful, there's a chance that millions of people around the world may find a new lease on life. I won't pretend that I don't have my concerns about gene altering procedures, but in this case, I see so much opportunity to do wonderful things for so many who are now suffering from an incurable disease.

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    Default Re: In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

    Nowhere did the article mention that sickle cell anemia confers immunity from malaria. That may be one reason for its persistence in the population.
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    Veteran Member Mr. Wizard's Avatar
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    Default Re: In A 1st, Doctors In U.S. Use CRISPR Tool To Treat Patient With Genetic Disorder

    Excellent point!! The peoples most affected by sickle cell live or are descendants from areas where malaria is most common, like Sub-Saharan Africa, Latin America, and Southern Asia (India).

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