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Thread: How Remdesivir Works to Fight COVID-19 Inside the Body

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    Default How Remdesivir Works to Fight COVID-19 Inside the Body

    Emily Barone and Lon Tweeten
    May 21, 2020

    On May 1, the U.S Food and Drug Administration issued an emergency-use authorization of remdesivir, an experimental anti-viral drug. With this clearance, doctors in the U.S. are now allowed to use the drug to treat patients with severe cases of COVID-19.
    Remdesivir isn’t new. It was initially developed to treat Ebola and was also tested in the lab against SARS and MERS—two other coronaviruses that infect humans much like the virus that causes COVID-19. It never made it to the approval stage for those uses, but over the last four months, scientists desperate for options to help mitigate the coronavirus pandemic have been looking towards old drugs that could be repurposed. Remdesivir has in that time traveled an unprecedented path to regulatory approval, becoming one of the most promising therapies against COVID-19 to date.

    Read more: https://time.com/5839932/how-remdesi...ntent=20200522
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    Veteran Member Mr. Wizard's Avatar
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    Default Re: How Remdesivir Works to Fight COVID-19 Inside the Body

    As I understand it, zinc works in similar fashion as the drug remdesivir to stop coronavirus replication. The challenge for zinc is to get enough of it into the cells to be effective. According to researchers, there are several "natural" polyphenols that serve as ionophores, enhancing zinc's ablility to get inside cells. These ionophores include: quercetin, resveratrol, curcumin, and Epigallocatechin-gallate or ECCG. Read more: https://pubs.acs.org/doi/abs/10.1021/jf5014633#
    https://medium.com/@GrnStarsProj/cou...s-127a970a940f

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    Default Re: How Remdesivir Works to Fight COVID-19 Inside the Body

    I take both quercetin and curcumin; the latter is a separate supplement, but the quercetin comes bound with one form of vitamin C that I take. Part of my treatment for macular degeneration requires 100 mg of zinc a day.
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    Veteran Member Mr. Wizard's Avatar
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    Default Re: How Remdesivir Works to Fight COVID-19 Inside the Body

    Choline--which the body converts to phosphatidylcholine--also has shown to be a zinc ionophore. Makes sense since phosphatidylcholine comprises a large part of the cell membrane. High choline foods include: chicken, eggs, fish, pork, beef, shrimp, beans, broccoli, and green peas. The recommended daily intake for choline is 550 mg. for men and 450 mg. for women. An egg, for example, contains about 120 mg.

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    Veteran Member Mr. Wizard's Avatar
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    Default Re: How Remdesivir Works to Fight COVID-19 Inside the Body

    The manufacturer of remdesivir--Gilead Sciences--announced today (June 29, 2020) what it would charge for the only drug that has proven to work so far against COVID-19. Gilead will charge $2,340.00 for a 5-day supply of the drug to U.S. government programs, like Medicaid, Veterans Hospitals, etc. For people covered by private health insurance, Gilead will charge $3,120.00, or 33% more. For uninsured patients, the recently-passed CARES Act (Coronavirus Aid, Relief, Economic Security Act) should cover the costs. Curiously, the clinical trials showed that remdesivir was effective after a 10 day course of treatment. Since all of the above prices are for a 5 day supply, I guess everything should be doubled. Keep Reading: https://www.statnews.com/2020/06/29/...b404-150918637

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    Default Re: How Remdesivir Works to Fight COVID-19 Inside the Body

    Kind of makes one regret that one never focused on a career in pharmaceuticals.
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