How the Oxford-AstraZeneca Vaccine Work

[Islander]

Jonathan Corum and Carl Zimmer
Jan. 8, 2021

The University of Oxford partnered with the British-Swedish company AstraZeneca to develop and test a coronavirus vaccine known as ChAdOx1 nCoV-19 or AZD1222. A clinical trial revealed the vaccine was 62 to 90 percent effective, depending on the initial dosage. Despite some uncertainty over trial results, Britain authorized the vaccine for emergency use in December, and India authorized a version of the vaccine called Covishield on Jan. 3.
The SARS-CoV-2 virus is studded with proteins that it uses to enter human cells. These so-called spike proteins make a tempting target for potential vaccines and treatments.
The Oxford-AstraZeneca vaccine is based on the virus’s genetic instructions for building the spike protein. But unlike the Pfizer-BioNTech and Moderna vaccines, which store the instructions in single-stranded RNA, the Oxford vaccine uses double-stranded DNA.

Keep reading: https://www.nytimes.com/interactive/...9-vaccine.html

[Swhealth]

I've read somewhere (maybe in other forum) that some people prefer the use of Oxford vaccine than of Moderna, I wonder why? I haven't seen any news lately about Moderna vaccine.

[Islander]

Its method of action (it's another mRNA vaccine) is very similar to the Pfizer vaccine, both of which are in use here. The Moderna's advantage is that it doesn't require the deep freezing temperature of the Pfizer vaccine, meaning that it's much more adaptable to small town and rural locales. Although supplies are unexpectedly limited and people are queuing up to get one, there is still a great deal about each of these that is unknown, since neither of them has completed all possible trials. That's why it has been granted emergency authorization by the FDA, as opposed to blanket approval.

[Swhealth]

I decided to take AstraZeneca vaccine instead because I find it the safest vaccine for my condition. Are you ladies open for taking vaccine? If yes, do you have any preference?